This clinical trial looks to see if the medication tadalafil can help with memory and thinking in the early stages of Alzheimer’s Disease dementia OR with Mild Cognitive Impairment.

What Happens In This Study?

You will either be given a medicine called tadalafil or a placebo (a dummy pill that looks like the medicine but has no active ingredients). Neither you, nor the research team, will know which group you are in.

Can I Join This Study?

To take part in this medical trial, you must meet these 8 requirements:

1. Your Diagnosis: A doctor must have confirmed that you have Mild Cognitive Impairment OR Alzheimer’s Disease.
2. Your Age: You are 50 years old, or older.
3. Your Symptoms: If you have been diagnosed with Alzheimer’s Disease, these symptoms should be mild to moderate. A doctor will be able to assess your symptom severity. Mild Cognitive Impairment symptoms are always mild.
4. Your Current Medicine: You must have been taking the same medication for at least the last 3 months without making any big changes to it.
5. Your Study Partner: You must have a reliable friend of family member who knows you well and you see regularly, who can also take part to provide us with information on how you are doing.
6. Your Permission: You must be able to understand what happens in the study and sign a form (called informed consent) to say you agree to join.
7. Your Time: You must do your best to attend all your study visits, and follow the rules of the study until it ends.
8. Taking the Medicine: You must be willing and able to swallow the trial medication.

Study Length: 1 year and 1 month

Number of appointments: 7 visits,

More information on the trial can be found on the Imperial website.