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Neuroprogressive and Dementia Network NHS Lothian | Our Services

EJS-ACT-PD

Edmond J. Safra Accelerating Clinical Trials in Parkinson’s disease

EJS ACT PD

Project Details

Start Date
Late 2026

Status
Study in Setup

Principal Investigator
Dr David Breen

NDN Study Lead
Emma Fleming

Main Research Site
Western General Hospital

This clinical trial looks to try different medications to see if they can slow down or stop Parkinson’s Disease symptoms from getting worse.

What Happens In This Study?

In this study, we test several different medications at the same time, while everyone keeps taking their usual Parkinson’s medication. Each treatment is given to a different group and compared with a placebo, which is a dummy drug with no active treatment.

Can I Join This Study?

To take part in this medical trial, you must meet these 7 requirements:

  1. Your Diagnosis: A doctor must have confirmed that you have Parkinson’s Disease.
  2. Your Age: You are between 30 years old or older. There is no upper age limit.
  3. Your Current Medicine: You must have been taking Parkinson’s medication (containing levodopa) for at least the last 2 months without making any big changes to it.
  4. Your Symptoms: Your Parkinson’s Disease symptoms should be mild to moderate. A doctor will be able to assess your symptom severity.
  5. Your Permission: You must be able to understand what happens in the study and sign a form (called informed consent) to say you agree to join.
  6. Your Time: You must do your best to attend all your study visits, and follow the rules of the study until it ends.
  7. Taking the Medicine: You must be willing and able to swallow the trial medication.

Study Length: 165 weeks (3 years and 1 month)

Number of appointments: 10 visits, plus check in phone calls

More information on the trial can be found on the EJS-ACT-PD website.

Meet the Study Team

NDN Principal Investigator: Dr David Breen

Consultant in Neurology

NDN Study Lead: Emma Fleming

Clinical Studies Officer

To find out more about this research study, please contact:
loth.sdcrn@nhs.scot
0131 537 3804

Funding and Sponsors

UCL Logo
Newcastle University

CONTACT INFORMATION

Neuroprogressive & Dementia Research Network Office

Old Pharmacy Building
Western General Hospital
Edinburgh
EH4 2XU

Email: loth.sdcrn@nhs.scot

Telephone: 0131 537 3804

ABOUT US

The NRS Neuroprogressive Disease and Dementia Network team in NHS Lothian conduct commercial and investigator led studies for: Alzheimers disease, Parkinsons disease, Huntingtons disease, Motor Neurone Disease, dementia with Lewy bodies, Progressive Supranuclear Palsy and Multiple System Atrophy.

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