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TOP HAT
https://services.nhslothian.scot/neuroprogressiveanddementianetwork/top-hat/
Trial of Ondansetron as a Parkinson’s Hallucinations Treatment TOP HAT is a multi-centre, double blind, randomized, placebo-controlled, parallel group trial of flexibly dosed ondansetron, as a treatment for Parkinson’s hallucinations, with a 12-week primary outcome and follow-up to 24 weeks. The primary objective of the trial is to establish whether flexibly dosed ondansetron will effectively
CHIEF-PD
https://services.nhslothian.scot/neuroprogressiveanddementianetwork/chief-pd-2/
Parkinson’s Disease Research The CHIEF-PD trial is a phase 3 randomized, double-blind, placebo-controlled trial of rivastigmine to prevent falls in Parkinson’s disease. The trial aims to determine whether treatment with cholinesterase inhibitors (ChEi) reduces the rate of falls in Parkinson’s disease. The primary objective of the trial is to determine the difference in fall rate
