{"id":3219,"date":"2026-08-24T12:32:00","date_gmt":"2026-08-24T11:32:00","guid":{"rendered":"https:\/\/services.nhslothian.scot\/neuroprogressiveanddementianetwork\/?page_id=3219"},"modified":"2026-08-24T13:34:08","modified_gmt":"2026-08-24T12:34:08","slug":"fiesta","status":"publish","type":"page","link":"https:\/\/services.nhslothian.scot\/neuroprogressiveanddementianetwork\/fiesta\/","title":{"rendered":"FIESTA"},"content":{"rendered":"\n
<\/div>
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Focused Investigation of the Efficacy and Safety of Tadalafil in Alzheimer’s Disease<\/strong><\/h1>\n\n\n\n

FIESTA: Evaluating the safety and efficacy of PDE-5 inhibitor, tadalafil, as a treatment for early stages of Alzheimer’s disease<\/strong><\/h3>\n<\/div><\/div><\/div><\/div><\/div>\n\n\n\n
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\"Fiesta<\/figure>
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Project Details<\/strong><\/p>\n\n\n\n

Start Date
End of 2026<\/strong><\/p>\n\n\n\n

Status
Site in Setup<\/strong><\/p>\n\n\n\n

Principal Investigator
Dr Catherine Pennington<\/a><\/a><\/p>\n\n\n\n

NDN Study Lead
Jessica Crossan<\/a><\/p>\n\n\n\n

Main Research Site
Western General Hospital<\/strong><\/p>\n<\/div><\/div>\n\n\n\n

This clinical trial looks to see if the medication tadalafil <\/strong>can help with memory and thinking <\/strong>in the early stages of Alzheimer\u2019s Disease dementia OR with Mild Cognitive Impairment<\/strong>.<\/strong><\/p>\n\n\n\n

What Happens In This Study?<\/strong><\/p>\n\n\n\n

You will either be given a medicine called tadalafil <\/strong>or a placebo<\/strong> (a dummy pill that looks like the medicine but has no active ingredients). Neither you, nor the research team, will know which group you are in.<\/p>\n\n\n\n

Can I Join This Study?<\/strong><\/p>\n\n\n\n

To take part in this medical trial, you must meet these 8 requirements<\/strong>:<\/p>\n\n\n\n

    \n
  1. Your Diagnosis:<\/strong> A doctor must have confirmed that you have Mild Cognitive Impairment OR Alzheimer\u2019s Disease<\/strong>.<\/li>\n\n\n\n
  2. Your Age:<\/strong> You are 50 years old, or older<\/strong>.<\/li>\n\n\n\n
  3. Your Symptoms: <\/strong>If you have been diagnosed with Alzheimer\u2019s Disease, these<\/strong> symptoms should be mild to moderate<\/strong>. A doctor will be able to assess your symptom severity. Mild Cognitive Impairment <\/strong>symptoms are always mild.<\/li>\n\n\n\n
  4. Your Current Medicine:<\/strong> You must have been taking the same medication for at least the last 3 months<\/strong> without making any big changes to it.<\/li>\n\n\n\n
  5. Your Study Partner:<\/strong>\u00a0You must have\u00a0a reliable friend of family member<\/strong>\u00a0who knows you well and you see regularly, who can also take part to provide us with information on how you are doing.<\/li>\n\n\n\n
  6. Your Permission:<\/strong> You must be able to understand what happens in the study and sign a form (called informed consent<\/strong>) to say you agree to join.<\/li>\n\n\n\n
  7. Your Time:<\/strong> You must do your best to attend all your study visits, and follow the rules of the study until it ends.<\/li>\n\n\n\n
  8. Taking the Medicine:<\/strong> You must be willing and able to swallow the trial medication.<\/li>\n<\/ol>\n\n\n\n

    Study Length<\/strong>: 1 year and 1 month<\/p>\n\n\n\n

    Number of appointments<\/strong>: 7 visits,<\/p>\n\n\n\n

    More information on the trial can be found on the Imperial website<\/a>.<\/p>\n<\/div><\/div>\n\n\n\n

    Meet the Study Team<\/h2>
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    NDN Principal Investigator: <\/strong>Catherine Pennington<\/p>\n\n\n

    \n
    \"\"<\/a>
    Consultant in Neurology<\/figcaption><\/figure>\n<\/div><\/div>\n\n\n\n
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    NDN Study Lead: <\/strong><\/strong>Jessica Crossan<\/p>\n\n\n

    \n
    \"\"<\/a>
    Senior Clinical Studies Officer<\/figcaption><\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n

    To find out more about this research study, please contact:
    loth.sdcrn@nhs.scot<\/a>
    0131 537 3804<\/strong><\/strong><\/p>\n<\/div><\/div>\n\n\n\n

    Funding and Sponsors<\/h2>
    \n
    \n
    \n
    \"Imperial<\/a><\/figure>\n<\/div><\/div>\n\n\n\n
    \n
    \"Alzheimer's<\/a><\/figure>\n<\/div><\/div>\n\n\n\n
    \n
    \"Alzheimer's<\/a><\/figure>\n<\/div><\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n
    <\/div>
    <\/div><\/div>
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    \n

    CONTACT INFORMATION<\/strong><\/p>\n\n\n\n

    Neuroprogressive & Dementia Research Network Office<\/p>\n\n\n\n

    Old Pharmacy Building
    Western General Hospital
    Edinburgh
    EH4 2XU<\/p>\n\n\n\n

    Email: loth.sdcrn@nhs.scot<\/a><\/p>\n\n\n\n

    Telephone: 0131 537 3804<\/strong><\/p>\n<\/div>\n\n\n\n

    \n

    ABOUT US<\/strong><\/p>\n\n\n\n

    The NRS Neuroprogressive Disease and Dementia Network team in NHS Lothian conduct commercial and investigator led studies for: Alzheimers disease, Parkinsons disease, Huntingtons disease, Motor Neurone Disease, dementia with Lewy bodies, Progressive Supranuclear Palsy and Multiple System Atrophy.<\/p>\n\n\n\n

    <\/p>\n\n\n\n

    \u00a9 NHS LOTHIAN | YOUR SERVICE.<\/strong><\/sub><\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

    Project Details Start DateEnd of 2026 StatusSite in Setup Principal InvestigatorDr Catherine Pennington NDN Study Lead Jessica Crossan Main Research SiteWestern General Hospital This clinical trial looks to see if the medication tadalafil can help with memory and thinking in the early stages of Alzheimer’s Disease dementia OR with Mild Cognitive Impairment. What Happens In<\/p>\n","protected":false},"author":382,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_gspb_post_css":"","footnotes":""},"categories":[],"class_list":["post-3219","page","type-page","status-publish","hentry"],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":"marianmontanha","author_link":"https:\/\/services.nhslothian.scot\/neuroprogressiveanddementianetwork\/author\/marianmontanha\/"},"rttpg_comment":0,"rttpg_category":false,"rttpg_excerpt":"Project Details Start DateEnd of 2026 StatusSite in Setup Principal InvestigatorDr Catherine Pennington NDN Study Lead Jessica Crossan Main Research SiteWestern General Hospital This clinical trial looks to see if the medication tadalafil can help with memory and thinking in the early stages of Alzheimer’s Disease dementia OR with Mild Cognitive Impairment. What Happens In","_links":{"self":[{"href":"https:\/\/services.nhslothian.scot\/neuroprogressiveanddementianetwork\/wp-json\/wp\/v2\/pages\/3219","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/services.nhslothian.scot\/neuroprogressiveanddementianetwork\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/services.nhslothian.scot\/neuroprogressiveanddementianetwork\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/services.nhslothian.scot\/neuroprogressiveanddementianetwork\/wp-json\/wp\/v2\/users\/382"}],"replies":[{"embeddable":true,"href":"https:\/\/services.nhslothian.scot\/neuroprogressiveanddementianetwork\/wp-json\/wp\/v2\/comments?post=3219"}],"version-history":[{"count":2,"href":"https:\/\/services.nhslothian.scot\/neuroprogressiveanddementianetwork\/wp-json\/wp\/v2\/pages\/3219\/revisions"}],"predecessor-version":[{"id":3225,"href":"https:\/\/services.nhslothian.scot\/neuroprogressiveanddementianetwork\/wp-json\/wp\/v2\/pages\/3219\/revisions\/3225"}],"wp:attachment":[{"href":"https:\/\/services.nhslothian.scot\/neuroprogressiveanddementianetwork\/wp-json\/wp\/v2\/media?parent=3219"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/services.nhslothian.scot\/neuroprogressiveanddementianetwork\/wp-json\/wp\/v2\/categories?post=3219"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}