{"id":1172,"date":"2026-02-12T13:56:00","date_gmt":"2026-02-12T13:56:00","guid":{"rendered":"https:\/\/services.nhslothian.scot\/neonatalunit\/?page_id=1172"},"modified":"2026-02-12T13:56:59","modified_gmt":"2026-02-12T13:56:59","slug":"acumen-3","status":"publish","type":"page","link":"https:\/\/services.nhslothian.scot\/neonatalunit\/initiatives-and-research\/acumen-3\/","title":{"rendered":"ACUMEN"},"content":{"rendered":"\n<p><strong>ACUMEN: <u>Acu<\/u>te High Dose <u>M<\/u>elatonin for <u>E<\/u>ncephalopathy of the <u>N<\/u>ewborn<\/strong><\/p>\n\n\n\n<p><strong>Phase I<\/strong> Dose Escalation and Cohort Expansion study to affirm the safety of pharmacological doses of a novel formulation of intravenous melatonin in babies with hypoxic-ischaemic encephalopathy (HIE) to augment therapeutic hypothermia (HT) treatment; to reduce the incidence and severity of disability in babies with moderate-severe HIE.<\/p>\n\n\n\n<p>Website &#8211; <a href=\"https:\/\/www.acumen-trial.co.uk\/\">ACUMEN study<\/a><\/p>\n\n\n<style>.wp-block-kadence-advancedgallery .kb-gallery-type-masonry.kb-gallery-id-1172_891f72-36{margin:-5px;}.kb-gallery-type-masonry.kb-gallery-id-1172_891f72-36 .kadence-blocks-gallery-item{padding:5px;}.kb-gallery-id-1172_891f72-36 .kadence-blocks-gallery-item .kb-gal-image-radius, .kb-gallery-id-1172_891f72-36 .kb-slide-item .kb-gal-image-radius img{border-radius:0px 0px 0px 0px;;}<\/style><div class=\"kb-gallery-wrap-id-1172_891f72-36 alignnone wp-block-kadence-advancedgallery\"><ul class=\"kb-gallery-ul kb-gallery-non-static kb-gallery-type-masonry kb-masonry-init kb-gallery-id-1172_891f72-36 kb-gallery-caption-style-bottom-hover kb-gallery-filter-none\" data-image-filter=\"none\" data-item-selector=\".kadence-blocks-gallery-item\" data-lightbox-caption=\"true\" data-columns-xxl=\"3\" data-columns-xl=\"3\" data-columns-md=\"3\" data-columns-sm=\"2\" data-columns-xs=\"1\" data-columns-ss=\"1\"><li class=\"kadence-blocks-gallery-item\" tabindex=\"0\"><div class=\"kadence-blocks-gallery-item-inner\"><figure class=\"kb-gallery-figure kadence-blocks-gallery-item-hide-caption\"><div class=\"kb-gal-image-radius\" style=\"max-width:473px;\"><div class=\"kb-gallery-image-contain kadence-blocks-gallery-intrinsic\" style=\"padding-bottom:43%;\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/services.nhslothian.scot\/neonatalunit\/wp-content\/uploads\/sites\/139\/2026\/02\/acumen.png\" width=\"473\" height=\"208\" alt=\"acumen\" data-full-image=\"https:\/\/services.nhslothian.scot\/neonatalunit\/wp-content\/uploads\/sites\/139\/2026\/02\/acumen.png\" data-light-image=\"https:\/\/services.nhslothian.scot\/neonatalunit\/wp-content\/uploads\/sites\/139\/2026\/02\/acumen.png\" data-id=\"1186\" class=\"wp-image-1186\" srcset=\"https:\/\/services.nhslothian.scot\/neonatalunit\/wp-content\/uploads\/sites\/139\/2026\/02\/acumen.png 473w, https:\/\/services.nhslothian.scot\/neonatalunit\/wp-content\/uploads\/sites\/139\/2026\/02\/acumen-300x132.png 300w\" sizes=\"auto, (max-width: 473px) 100vw, 473px\" \/><\/div><\/div><\/figure><\/div><\/li><\/ul><\/div>\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-vimeo wp-block-embed-vimeo wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"ACUMEN Animation FINAL July 2025 with SUBS\" src=\"https:\/\/player.vimeo.com\/video\/1103113008?dnt=1&amp;app_id=122963\" width=\"1520\" height=\"855\" frameborder=\"0\" allow=\"autoplay; fullscreen; picture-in-picture; clipboard-write; encrypted-media; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\"><\/iframe>\n<\/div><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>ACUMEN: Acute High Dose Melatonin for Encephalopathy of the Newborn Phase I Dose Escalation and Cohort Expansion study to affirm the safety of pharmacological doses of a novel formulation of intravenous melatonin in babies with hypoxic-ischaemic encephalopathy (HIE) to augment therapeutic hypothermia (HT) treatment; to reduce the incidence and severity of disability in babies with<\/p>\n","protected":false},"author":309,"featured_media":0,"parent":818,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_searchwp_excluded":"","footnotes":""},"categories":[],"class_list":["post-1172","page","type-page","status-publish","hentry"],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":"scottsamson","author_link":"https:\/\/services.nhslothian.scot\/neonatalunit\/blog\/author\/scottsamson\/"},"rttpg_comment":0,"rttpg_category":false,"rttpg_excerpt":"ACUMEN: Acute High Dose Melatonin for Encephalopathy of the Newborn Phase I Dose Escalation and Cohort Expansion study to affirm the safety of pharmacological doses of a novel formulation of intravenous melatonin in babies with hypoxic-ischaemic encephalopathy (HIE) to augment therapeutic hypothermia (HT) treatment; to reduce the incidence and severity of disability in babies with","_links":{"self":[{"href":"https:\/\/services.nhslothian.scot\/neonatalunit\/wp-json\/wp\/v2\/pages\/1172","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/services.nhslothian.scot\/neonatalunit\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/services.nhslothian.scot\/neonatalunit\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/services.nhslothian.scot\/neonatalunit\/wp-json\/wp\/v2\/users\/309"}],"replies":[{"embeddable":true,"href":"https:\/\/services.nhslothian.scot\/neonatalunit\/wp-json\/wp\/v2\/comments?post=1172"}],"version-history":[{"count":4,"href":"https:\/\/services.nhslothian.scot\/neonatalunit\/wp-json\/wp\/v2\/pages\/1172\/revisions"}],"predecessor-version":[{"id":1246,"href":"https:\/\/services.nhslothian.scot\/neonatalunit\/wp-json\/wp\/v2\/pages\/1172\/revisions\/1246"}],"up":[{"embeddable":true,"href":"https:\/\/services.nhslothian.scot\/neonatalunit\/wp-json\/wp\/v2\/pages\/818"}],"wp:attachment":[{"href":"https:\/\/services.nhslothian.scot\/neonatalunit\/wp-json\/wp\/v2\/media?parent=1172"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/services.nhslothian.scot\/neonatalunit\/wp-json\/wp\/v2\/categories?post=1172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}