{"id":360,"date":"2025-06-03T13:45:00","date_gmt":"2025-06-03T12:45:00","guid":{"rendered":"https:\/\/services.nhslothian.scot\/geneticservice\/postnatal-service\/"},"modified":"2025-06-03T13:45:55","modified_gmt":"2025-06-03T12:45:55","slug":"postnatal-service","status":"publish","type":"page","link":"https:\/\/services.nhslothian.scot\/geneticservice\/postnatal-service\/","title":{"rendered":"Postnatal Service"},"content":{"rendered":"\n<p>The Postnatal Cytogenetic Section performs constitutional chromosome analysis and microarray analysis on venous blood samples.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Referral Indications<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Microarray Studies<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Global Developmental Delay   (Please note; Microarray studies are not a screening tool.  They will only be used in cases with a confirmed diagnosis:  Please see our <a rel=\"noreferrer noopener\" href=\"https:\/\/services.nhslothian.scot\/geneticservice\/cytogenomic-tests\/\" target=\"_blank\">Cytogenomics page<\/a> for more information)<\/li>\n\n\n\n<li>Multiple congenital abnormalities suggestive of a chromosome abnormality<\/li>\n\n\n\n<li>Microdeletion or duplication syndromes<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">G-Banded Chromosome (karyotyping) Studies<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Delayed puberty or inappropriate secondary sexual development<\/li>\n\n\n\n<li>Ambiguous genetalia or indeterminate sex<\/li>\n\n\n\n<li>Short stature, amenorrhoea in females<\/li>\n\n\n\n<li>Oligospermia or azoospermia in males<\/li>\n\n\n\n<li>Family history of a known chromosome abnormality other than simple aneuploidy due to non-disjunction<\/li>\n\n\n\n<li>Suspected family history of chromosome abnormality where the karyotype of the affected individual is not known<\/li>\n\n\n\n<li>Sperm and egg donors<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Other<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Chromosome breakage studies (Samples should be sent to the <a rel=\"noreferrer noopener\" href=\"https:\/\/www.nhsgrampian.org\/service-hub\/north-of-scotland-medical-genetics\/cytogenetics\/\" target=\"_blank\">Aberdeen Cytogenetics Laboratory<\/a><strong>. DO NOT SEND TO EDINBURGH LAB<\/strong>.  Samples must arrive at the Aberdeen Lab less than 5 days after sampling.)<\/li>\n<\/ul>\n\n\n\n<p><a href=\"https:\/\/services.nhslothian.scot\/geneticservice\/request-forms\/\" data-type=\"page\" data-id=\"348\">Referral forms<\/a>&nbsp;can be downloaded.<\/p>\n\n\n\n<p>Note: Referring clinicians are requested to comply with NHS Lothian policy on&nbsp;<a href=\"https:\/\/services.nhslothian.scot\/geneticservice\/mandatory-datasets\/\" data-type=\"page\" data-id=\"353\">Mandatory Data Sets<\/a>:&nbsp; Failure to do so will result in delays in processing or rejection of the sample.<\/p>\n\n\n\n<p>Any special requirements (e.g. Molecular Cytogenetic (FISH), urgent result) must be discussed by telephone with either Head of Service (0131 537 1156) or Head of Section (0131 537 1183)\u00a0before taking and sending the sample.<\/p>\n\n\n\n<p>Arrange for immediate transport to the Laboratory.&nbsp; If this is not available, blood specimens should be placed in a cool place or at 5\u00b0C in a refrigerator (<strong>DO NOT FREEZE<\/strong>).&nbsp; It is advisable to telephone the Laboratory on 0131 537 1183&nbsp;to alert the Laboratory as, occasionally, specimens are lost during transport.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Rapid Trisomy Analysis<\/h2>\n\n\n\n<p>Rapid QF-PCR trisomy screening can be offered in addition to the karyotyping service where there is a clear indication of Trisomy 21. Any other referrals for this service must be discussed with Clinical Genetics<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Male Factor Infertility Kit<\/h2>\n\n\n\n<p>Y chromosomal microdeletions are the second most common cause of male infertility after Klinefelter\u2019s syndrome with deletion frequencies varying between 2 and 10% in azoospermic men, dependent on patient selection (Krausz et al., 2013).<br>Clinically relevant deletions have been identified in three regions of the Y chromosome, AZFa, AZFb and AZFc.<br>Testing of Y microdeletion by QF-PCR is available for patients with azoospermia (sperm concentrations &lt; 2&#215;10^6\/ml).<br>Please note:&nbsp; This test requires 2-5mL of peripheral blood in an EDTA tube.<\/p>\n\n\n\n<p>Details of Limitations of&nbsp;<a href=\"https:\/\/services.nhslothian.scot\/geneticservice\/limitations-of-test\/\" data-type=\"page\" data-id=\"352\">Cytogenetic investigations&nbsp;<\/a>are available.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Postnatal Cytogenetic Section performs constitutional chromosome analysis and microarray analysis on venous blood samples. Referral Indications Microarray Studies G-Banded Chromosome (karyotyping) Studies Other Referral forms&nbsp;can be downloaded. Note: Referring clinicians are requested to comply with NHS Lothian policy on&nbsp;Mandatory Data Sets:&nbsp; Failure to do so will result in delays in processing or rejection of<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":40,"comment_status":"closed","ping_status":"closed","template":"page-templates\/widewidth.php","meta":{"footnotes":""},"categories":[],"class_list":["post-360","page","type-page","status-publish","hentry"],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":"NHS Lothian","author_link":"https:\/\/services.nhslothian.scot\/geneticservice\/author\/nhs-lothian\/"},"rttpg_comment":0,"rttpg_category":false,"rttpg_excerpt":"The Postnatal Cytogenetic Section performs constitutional chromosome analysis and microarray analysis on venous blood samples. Referral Indications Microarray Studies G-Banded Chromosome (karyotyping) Studies Other Referral forms&nbsp;can be downloaded. Note: Referring clinicians are requested to comply with NHS Lothian policy on&nbsp;Mandatory Data Sets:&nbsp; Failure to do so will result in delays in processing or rejection of","_links":{"self":[{"href":"https:\/\/services.nhslothian.scot\/geneticservice\/wp-json\/wp\/v2\/pages\/360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/services.nhslothian.scot\/geneticservice\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/services.nhslothian.scot\/geneticservice\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/services.nhslothian.scot\/geneticservice\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/services.nhslothian.scot\/geneticservice\/wp-json\/wp\/v2\/comments?post=360"}],"version-history":[{"count":5,"href":"https:\/\/services.nhslothian.scot\/geneticservice\/wp-json\/wp\/v2\/pages\/360\/revisions"}],"predecessor-version":[{"id":1370,"href":"https:\/\/services.nhslothian.scot\/geneticservice\/wp-json\/wp\/v2\/pages\/360\/revisions\/1370"}],"wp:attachment":[{"href":"https:\/\/services.nhslothian.scot\/geneticservice\/wp-json\/wp\/v2\/media?parent=360"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/services.nhslothian.scot\/geneticservice\/wp-json\/wp\/v2\/categories?post=360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}