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\u200bCancer Genetics<\/u><\/strong><\/p>\n\n\n\n <\/p>\n\n\n\n Cancer is a common illness expected to affect 1 in 2 people in their lifetime. Therefore, many people will have some family history of cancer. Most of these cancers happen by chance rather than having an inherited cause. Only around 5-10% of cancers have an inherited component.<\/p>\n\n\n\n The cancer genetics service performs risk assessments for patients affected by cancer and\/or with a family history of cancer to determine how likely it is that the cancer is inherited, what an individual\u2019s risk is, whether genetic testing is possible or appropriate and what measures can be taken to manage or minimise inherited cancer risks.<\/p>\n\n\n\n We have developed the following guidance for Healthcare Professionals to assess which patients meet our referral criteria.<\/p>\n\n\n\n Once you have read the guidance, if you are still uncertain whether your patient should be referred, please email WGH.ClinicalGenetics@nhslothian.scot.nhs.uk. Alternatively, you can contact us on 0131 537 1116 and ask for the Duty Genetic Counsellor<\/p>\n\n\n\n <\/p>\n\n\n\n <\/p>\n\n\n\n Patients who have not had cancer but report a family history of cancer should be directed to complete our family history questionnaire<\/strong> if they meet any of the family history criteria on the pages below:<\/p>\n\n\n\n Referral Guidelines Patients with a personal or family history of breast cancer The patient should only be directed to the Family History Questionnaire, if you believe that the family history is significant.<\/strong> <\/p>\n\n\n\n Referrals are triaged by the Clinical Genetics team. Depending on the family history, an assessment may be completed by letter <\/strong>or appointment<\/strong>.<\/p>\n<\/div><\/div>\n\n\n\n <\/p>\n\n\n\n Patients affected by cancer will be offered genetic testing if they meet any of the criteria for genetic testing listed in the Scottish Genetic Test Directory. This can be found at the link below:<\/p>\n\n\n\n National Test Directory<\/a><\/p>\n\n\n\n Patients with a personal cancer diagnosis who are eligible for genetic testing, who have not already had genetic testing undertaken as part of their treatment, can be referred directly to Clinical Genetics via:<\/p>\n\n\n\n OR<\/strong><\/p>\n\n\n\n OR<\/strong><\/p>\n\n\n\n Referral Administration<\/p>\n\n\n\n SE Scotland Clinical Genetics Service<\/p>\n\n\n\n Western General Hospital<\/p>\n\n\n\n Crewe Road South<\/p>\n\n\n\n Edinburgh<\/p>\n\n\n\n EH4 2XU<\/p>\n<\/div><\/div>\n\n\n\n <\/p>\n\n\n\n If a likely pathogenic or pathogenic variant in a known cancer predisposition gene e.g. BRCA1, has already been identified in a family member, these patients should be referred directly to Clinical Genetics with the name and date of birth of the relative, the gene in which the variant has been identified and where they were tested. If your patient has been given a letter from a Genetics service and\/or a test report from a relative, it is extremely useful if a copy of this is attached to the referral.<\/p>\n\n\n\n Referrals can be sent via:<\/p>\n\n\n\n OR<\/strong><\/p>\n\n\n\n OR<\/strong><\/p>\n\n\n\n Referral Administration<\/p>\n\n\n\n SE Scotland Clinical Genetics Service<\/p>\n\n\n\n Western General Hospital<\/p>\n\n\n\n Crewe Road South<\/p>\n\n\n\n Edinburgh<\/p>\n\n\n\n EH4 2XU<\/p>\n<\/div><\/div>\n\n\n\n <\/p>\n\n\n\n Any patients that do not meet referral criteria will likely have a risk of cancer similar to the general population. Please reassure these patients that they do not have a significantly increased risk of cancer. For these patients, the most effective way to reduce the risk of cancer is to lead a healthy lifestyle and the resources below may be helpful for patients:<\/p>\n\n\n\n Home – Scottish Cancer Prevention Network (cancerpreventionscotland.org.uk)<\/a><\/p>\n\n\n\n Healthy living | NHS inform<\/a><\/p>\n\n\n\n Can cancer be prevented? | How to reduce your risk of cancer (cancerresearchuk.org)<\/a><\/p>\n\n\n\n Get Checked Early<\/a><\/p>\n\n\n\n Causes and risk factors | Macmillan Cancer Support<\/a><\/p>\n\n\n\nHow to refer<\/span><\/strong><\/h2>\n\n\n\n
Patients with a family history of cancer:<\/u><\/strong><\/h2>
<\/a>Patients with a personal or family history of colon cancer
<\/a>Personal or family history of ovarian cancer<\/a><\/p>\n\n\n\n<\/ol>\n\n\n\n
Patients with a personal diagnosis of cancer:<\/u><\/strong><\/h2>
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Patients with a known pathogenic variant\/genetic alteration in the family:<\/u><\/strong><\/h2>
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Patients that do not meet referral criteria:<\/u><\/strong><\/h2>